I don't use Epson Scan but there is a function in Photoshop CS4 called "Shadows & Hilights." I can tell you how that works then you can work backward from there and see if that helps.
Imagine your standard histogram. On the left end are shadows. On the right are highlights.
When you move the SHADOW slider, you are expanding the left/shadow tail of the histogram toward the right, thereby expanding the shadow information over a larger range of values. You decrease the contrast of your shadows.
When you move the HIGHLIGHT slider, you are expanding the right/detail tail of the histogram toward the left, thereby expanding the detail information over a larger range of values. You decrease the contrast of your highlights.
In other words, you can get more detail in dark areas of the picture by moving the shadow control and you can get more detail in the highlights by moving the highlight control.
But be careful. If you overdo it, you can end up with a picture that has a muddy, gray look to it. There is that "magic spot" in the settings where you'll see the picture look "just right." It can be tricky to find that spot.
Now, I hope we can translate that information to your use in your scanner software.
Personally, I prefer to avoid doing anything to alter the image during the scanning phase of my project. I want to get as clean a scan as possible. Then I import into Photoshop via Camera RAW and do my work there.
I envision it like putting an effect filter over the camera lens. Once you put an effect onto the image on-film, you can never take it back. If you can achieve the same effect in the darkroom or in Photoshop, why permanently alter your image on the film? If you ever decide that a photo would have been one of your "great ones" if it wasn't for that starburst effect around the sun, you could be slapping your self on the forehead.
That has happened to me.
Not to say that you shouldn't use shadow/highlight controls if you need to. I'm just telling you my experience. Last time I checked, we still lived in a free country.