Yes, it will affect your meter reading, but you can adjust the necessary number of stops either on the ASA setting on the film back, or with the exposure compensation on the AE finder. If you're going to use a split focus, a brighter screen won't really make a difference for focusing because the center part where the split line is won't be any brighter than the center of a Mamiya split focus screen. The rest of the screen is brighter, but not the center spot.
If you compensate for exposure with a brighter screen, the compensation factor will probably be different for spot mode than it is for average mode.