Don't use those cheap tear-away roll paper cutters designed for Kraft paper. You'll create a mess. Real XY automated cutters are quite expensive and can be finicky to maintain. If your rolls are not terribly wide, you could use a self-healing cutting mat and a cutting edge with a captured sliding mat knife blade like Fletcher offers. Some people just do it on the floor with a steel straightedge and handheld mat knife (sounds barbaric to me). Others do that on the wall with the paper roll suspended above.
Although I was offered a big automated XY cutter for free when a particular lab retired it, I just didn't want to deal with any expensive service headaches. So my own system involves a 48" wide dual-rail Rototrim cutter mounted flush adjacent to a Formica laminated 4X4 foot tabletop which has a perfectly square stainless steel guide at the right edge. Then at various places along its depth, front to back, are precisely positioned thread inserts which register two holes in another machined stainless edge, which can be repositioned at various exact paper cutoff lengths or widths as needed : 8", 10", 16",20", 24", 30", and 40". Below the front edge of the table is the roll holder itself, strong enough to support even heavy polyester rolls like Fujiflex. I'm just tyring to give a general idea; there are numerous other minor features. But all of this can be used in total darkness, though the bigger the roll, the fussier things become.
Anyone crazy enough to use a guillotine type paper cutter in the dark should at least inventory their fingers both before and after the procedure.