Yes QTR or quadtonerip is the software regularly referred to here for creating digital negatives. It is one of several methods for calibrating digital negatives along with Chartthrob, PDN, ect.
I use it as a standalone software, but I believe it can be used as a print driver. Others can chime in on that.
Yes, it allows you pretty complete control of all the various colors of ink. So for example, you can specify which color inks and their individual densities that will represent a middle grey in the image you are printing. In my case, for my cyanotype curve, middle grey will print a little density from matt black & yellow and more density from lt magenta, lt cyan and lt black.
It has a significant learning curve to get the hang of it. As you need to make an actual print from your revised curve to see it's effect. If you have a UV densitometer you can see the effects of your changes more quickly.
Go to Ron Reeders website for his most excellent tutorials on creating digital negatives with QTR and lots of curves you can download.