Looks like a processing problem to me. Looks like those stripes may result from uneven developr flow thru sprocket holes (if 35mm): inadequqte afitation or insufficient or exhausted developer.
Yep, 8 sprocket holes across the frame, these look evenly spaced and count for 8.
Maybe dodgy processing by the lab... labs always have given me shitty processing... on C41 normally though, my b&w was fine... do -all- my film at home now from b&w, c41 ro E6.
Anyway I have had severe "grain" before randomly from my V500 too, something to do with the resolution I selected and scan options, some kind of interferrence pattern I gather.
Anyway, try scanning at 3200 dpi (pull down in photoshop after), and 16-bit grey scale, also make sure digital ICE is off, and turn off all other options to test.