One of the big problems, especially with flatbeds, is even though they look clean, often times minute dust particles will get inside under the scanner bed and rest on the CCT light that actually does the scanning, same thing happens with copy machines, which is one of the reasons why they have to be serviced so often...if you can carefully take the halves of the scanner apart, you might be able to use some air to clean the inside, I would not recommend it unless your real familier with computer periphials.
Dave