Regarding high impedance instruments, instruments such as a Keithly high impedance electrometer periodically appear on ebay. Also, one could build a FET input amplifier. A JFET input stage might be suitable. Gate current of the FET gate might be a factor to consider, though it is generally low for JFETs. MOSFET input amplifiers generally have lower leakage and bias currents, so this is a possibility, though MOSFETs have other issues, especially sensitivity to static electricity.
Vacuum tube voltmeters are another possibility, though this is pretty antiquated technology.
Chopper stabilized amplifiers might be another possibility, though that might be getting pretty fancy/expensive, and with modern FETs this might not be needed. Anyway, if I recall chopper stabilization would typically be more useful for correcting for voltage noise issues than for input impedance issues.
Anyway some of these points might get the creative juices flowing.