I have both, so can give you a decent summary of the differences. But first let me note that, in either case, unless you have a lens this long VERY solidly supported on a heavy tripod with equally stiff attachment at the top, it won't make a bit of difference. Nearly every "sharpness" complaint I've heard (like Alan's observation in a previous post) was due to vibration due to an inadequate support. I mount mine DIRECTLY to the platform top of the same wooden Ries tripod as I use for an 8x10, or else an equivalently solid large CF tripod with a platform top. Now for the differences: The older 300's are decent lenses and currently an extreme bargain, if you want something that won't give you a heart attack if it gets damaged in use or stolen. You can do high quality black and white work with these, and they are OK for color too if the final image is not highly enlarged (plenty sharp for magazine work, for example). The newer 300EDIF is, well, one stunning optic. It was scarce for awhile because it was prized by widefield astrophotographers. There is far less color fringing than the ordinary MC 300 - nearly none a stop down, so you can make big color enlargements with no noticeable fringing, and not even a bit of halo when strong contrast filters are used in black and white photography. Another advantage is that it focuses much closer range than the older 300, so allows you to home in on details right across a road or whatever. Both have nice "bokeh", but the EDIF version especially so, since it is a solid performer even wide open. How do I mount mine - I use BOTH the tripod collar and the camera body thread, and unitize these onto a single solid hardwood & phenolic properly-shaped bar that in turn has a 3/8-16 thread to accept the tripod turnknob from below. Rock solid. I'm giving a hint. If you have a choice between getting bitten by a rattlesnake and buying the heaviest ballhead on the market for use with this lens, take the rattlesnake - it will be less grief. Do it right, and you'll have a wonderfully fun, exceptionally sharp system. I also happen to have a good Nikon adapter for this lens. But at high shutter speeds where mirror lockup is not necessary, I have successfully rested both these lenses on a jacket or baseball cap atop a car roof or fencepost, and semi-handheld them.