Years ago, I shot nothing but medium format, Tri-X (box speed) and D-76. Prints were stunning.
Fast forward 25+ years, I decided that a MF enlarger was too big for the hall bathroom that I was gonna commandeer on a part-time basis. So I opted for 35mm. See the attached link of a scanned 8 x 10 PRINT of mine.
(there was a url link here which no longer exists)
The tech data is wrong - we were all wondering what "Ultrafine Extreme ASA100" was...and some of us thought it was ORWO 100. So that photo is labeled (wrongly) with the tag UN54 (Orwo 100). It is Ultrafine Extreme 100 souped in DIAFINE. In this instance, with the tough lighting & shadows, the compensating nature of DIAFINE did a nice job. Grain? not much, the print was "creamy".
On that same roll, bright sunshine shots of the UN building from Roosevelt Island were very flat - oddly so.
I really don't even have any paper larger than 8 x 10, so I'm not sure I have the answer to your question. With modest cropping, I suppose I can still make a pretty good 8 x 10's at least with the right film & developer. Definition? Don't really know. Some museum prints look pretty good a few paces away, but when you get your nose up to them - it's different. I'm spoiled by my MF years.
Indeed, I find the most charm in small photos such as 3 1/2" x 5". Maybe, because of their size, they force one to really look at them, but I am really smitten by small photos. There is no link between my love of small photos and the fact that I wear tri-focals...............
Jerry