I have been using Neat Image for some while to remove this unfortunate characteristic of scanning colour neg films. Whatever the origins, C41 film looks awful in the 'grain' department fresh off the scanner compared to E6 and B+W negs.
It has been a major success - I can now use C41 film to obtain images which E6 wouldn't have handled.
I only use in 'Auto' setting since it seems to do all I want without having to tweak sliders; possibly cleaning image up too much in some instances. However not been motivated to try to expend energy learning yet more software intricacies.
To ease use, I have stored presets for film type, format and resolution. The latter being important as magnifies film grain/noise.