I made the following variations from default settings on my F100:
Set the autofocus switch next to the lens on continuous focus (no lock);
set the shutter release to lock the AE setting but not AF;
focus with the AF button on the back of the camera.
By doing this, with a static subject you can point the AF target at whatever you want to focus on and press and release the AF button to focus, then point the lens at the subject area you want to meter (especially if you use spot metering), hold down the shutter release, then compose the picture and shoot. This is basically how I work with manual cameras, and it makes it easier to switch over to the F100 or other AF Nikons.
If you are shooting a moving subject, just hold down the AF button and the AF will track the subject.