The ES-2 is designed to work out of the box with the 40mm f/2.8 DX Micro lens for APS-C bodies and the manual states that if you use a 55mm or 60mm lens with it on a DX camera it will crop out the edges of the film. That said, it's possible that a combination of extension tubes and accessory close-up lenses would allow you to use the 55mm. For color negatives, you would also have to apply the usual color correction -- I use VueScan to do so.
Here's something to think about, though. An ES-2 is $140, and a 40mm f/2.8 DX is about $200 used and $275 new. Depending on how many negatives you wish to scan and how you value your time, a scanning service may be a reasonable alternative.