I just got a 4000 ED. Matt (Albada) is correct. Nikon scan does not work with my Windows 10 or 7. It won't pick up the scanner. I'm using Vuescan which is good but the whole setup is finicky. I had to install a PCIe firewire and then figure out which computer it worked better with. As far as I stand after nearly a week of messing around the scanner only works on its side, with preview DPI set over 667 and the firewire to DV not Firewire to firewire port. Also, the 4000dpi files are massive, 150mb each. I scaled back to 2400 48bit to get about 50mb files.
This might be only me but this is pretty tricky. For B&W it's not really worth it, I'm going to stick with DSLR scanning. For color? The ICE makes such a major difference. Night and day.