Clay, interesting post. I have the LS-8000 and generally love it, and Nikon Scan (4.02) has been my default scanning software. I've not seen any ticky behavior out of it unless I've inadvertently left both my flatbed and the Nikon on at the same time (both Firewire). I scan in RGB but indicate "monochrome" for B&W. You have me curious about your malfunction.
I've had VueScan for a long time, but frankly I don't share the adulation others express for this software. I think the interface is clunky and the documentation, dismal. I'm not really that dense, but I can't get it to batch scan a four-image strip of 645 negatives--a trivially simple operation in Nikon Scan--and can't find documentation anywhere to explain how to do this. It's tough and nonintuitive for me to adjust curves, compared to the no-brainer ease of this in NS. I must be missing something obvious.
I plan/hope to upgrade my creaking Mac G4 to an intelMac screamer this year, and I'm concerned about Nikon Scan's future; Nikon hasn't said whether they'll upgrade it or port it to universal binary. That incentivizes me to finally get up to speed with VueScan, if only I could find a decent reference.
What I really want out of VueScan is the ability to preview scan a strip of negatives, adjust their curves like I do in NS, and then batch output scan them. I don't really need preconfigured profiles like VS's for this application.
If you can recommend a source for documentation I'd love to hear it, and thanks in advance.