Way back in the mid-80s, I bought a Sigma 600mm mirror and later bought a Canon FTb, specifically because it had mirror lock up. I used that Sigma to great success with the FTb in the mirror up position. About a year later, I bought an original F-1, specifically because it had mirror lock up and the New F-1 didn't. The original F-1 continues to be my favorite 35mm camera, and its mirror up feature is an important part of that. In fact, it is because of my preference for this feature, that most of the cameras I've collected over the years has it. The aforementioned Canons. Nikons F through F4. Pentax KX and LX. Minolta SRT-101. Oh, and my Bronica ETRSi and Pentax 67, both of which I bought specifically because they have MLU.
As to the question, how often do I use the mirror up feature of my cameras, my answer is "often." Whenever I'm shooting with one of my long lenses, I will often use a stout tripod and mirror up -- with a cable release.