I have had a C330 for about 30 years, and I picked up a mint C220 body about 4 years ago. I also have a selection of accessories (prism finder, paramender, filters, etc.) that probably enhance my use of the cameras.
The 220 is a bit smaller, and definitely lighter than the C330, but you lose the benefit of automatic shutter cocking.
The "used mostly for weddings" would give me some concern, as that could mean it and its lens(es) were used a lot, and used hard. I'd check it carefully for signs of abuse/damage, but if there are problems, they should be relatively easy to detect. My C330 has seen a fair number of weddings, and it isn't as pretty as it once was, but it has never needed any repair.
Make sure that the lens with it is a black body lens. The older, chrome lenses are good quality, but the shutters are a bit older, and if they go wrong, they are harder to get repaired.
The 80mm lenses are excellent. I have and use one happily, but I find that my favorite kit is the 135mm lens plus either the 65mm, or the 55mm.
The bellows means that close-up work is easy, provided that you learn how to deal with parallax (tripod and paramender the best way to go).
There is no depth of field preview (unless you have a relatively rare version of the 105mm lens that I've read and heard about, but never actually seen).
The site to check for Mamiya TLR info is Graham Patterson's site linked below. He posts regularly here on APUG under grahamp (IIRC).
Dead Link Removed
If you check my gallery here on APUG, you will see a few shots I took using my C220, including "Ropes", "Fall Foliage" and the shot I posted last night, "Mud, Glorious Mud".
I find I can carry the camera and two lens kit and a meter and some film in a very compact and reasonably light bag (noting however that my longest lens is the 135mm). I can squeeze my C330 body into the same bag, with the same lenses, but it is a bit of a squeeze.
In recent years I've expanded my MF choices with both Mamiya 645 SLR equipment and Koni-Omega 6x7 equipment, but I still like the results from my Mamiya TLRs.
The TLRs would probably be great for IR film too, but I haven't tried it.
Hope this helps.
Matt