In Single mode, you will only be able to make one exposure per frame. All the Mamiya twins have a quirk where a qentle pressure on the shutter release without tripping the shutter may trip the advance interlock. It varies between bodies and sometimes depends on the tension on the lens shutter release arm. Switching to Multi over-rides the film advance interlock, allowing the shutter to be retensioned and the body release to be used repeatedly.
When the lens panel is fully retracted, switching the side control to 'Unlock' will: raise the internal baffle to protect the film, lock the shutter release, and release the cam holding the lens retaining wire in the locked position. If the lens board is extended forward, the small metal finger that controls these functions does not engage.
The small slide control on the lens panel that physically locks the shutter release was introduced on later models than the C220.