The 645E is probably about 200 grams lighter than a similarly equipped (prism finder) 645 Pro.
The 645E is not designed to take a power winder, so it probably doesn't have the extra reinforced gearing that was incorporated into the 645 Pro (to deal with a potential weakness in the 645 Super).
As the 645E has a non-interchangeable prism, and doesn't take interchangeable backs, any damage or wear in those two parts cannot be fixed by a simple replacement. On the other hand, for the 645E there are no potential problems with the means of connecting those interchangeable parts.
The 645E was originally priced very favourably, and wasn't targeted toward the professional who would use it heavily. I doubt that it is as robust as a 645 Pro, but it is quite robust.
Most 645Es are quite young. Certainly, they are a lot younger than a 645 Super.
I have been considering replacing the 645 Super that serves as my backup body with a 645E.
I think the question of how much metal is in the body isn't a reliable measure of durability. All of the Mamiya 645s are made of strong and durable materials, because the plastic parts are strong as well.
Matt