I shooted many rolls with my Mamiya 645 and few weeks ago it decided to block in the middle of a roll.
The mirror was in "UP" position and impossible to unlock anything.
In the end I managed to remove the 120 back, rewind the film by hand and unlock the camera I don't know how... but as I never had this problem, I'm wondering if you know what can cause this.
I had this happen few times with M645Super. It seems (for me), replacing the battery cured the problem. Even when the "battery check" light comes on brightly, I was experiencing this issue.