I had a 6600 for a few months when I was living in Japan long ago. By comparison with the 4x5 LPL's, it felt flimsy and cheaply built.
The things that stand out for me about the 7451/4500II:
* Handles up to 4x5, though the light source is *just* large enough for 4x5 - if you want to print 4x5 with border, special measures are required
* Solidly built overall, though without the "heavy metal" feel of a big Beseler, Omega or Durst
* Controls function smoothly
* Alignment fixed in place at the factory - not really any joints that can drift out of alignment in typical use (but alignment does need checking, as some units have come misaligned from the factory - there are things that can be done to compensate for that if needed, depending exactly where the problem is)
* Diffusion light source suits me better than the condenser heads of the 6600 and of the Beseler 23CII I still have stashed in a corner of the basement
* Dichroic color head is extremely convenient for variable-contrast printing
* Combination of the optional 4x5 glass sandwich carrier and the optional masking stage is very handy for printing multiple formats with best quality
Overall, it's more flexible with different formats and feels much more like a professional-grade tool, while the 6600 felt more like a toy. [As it happens, there was also something misaligned in the illumination system of the 6600 I owned (and had purchased new in Tokyo and received directly from LPL), which I never did figure out. But that might have been a random sample defect.]
Although the 7450 doesn't have the same beefy column as the 7451/2/2L, my guess is that it will share most of the overall robust feel and features of the later models.