Well, front/back focus issues with even L lenses and all the Canon DSLR's are an on going problem. This is the bane of Canon, and perhaps the other makes. I've finally got my stable of lenses spot on, but it took years, and packages to Canon service. My 50L F1.2 still has issues however. I think no amount of calibration will mitigate it's issues; a design flaw that started during the blueprint drawings. Unlike the other L primes, the 50L does not use a floating design (idiots).