Generally, the more easterly route should be better, An if you can, take 395 for longer in Nevada and Oregon, rather than 95 and then 395, as your route shows. I say "better" because southeast Oregon and nearby Nevada is quite remote and very dry, and has lots of playas (dry or ephemeral lakes). The lighting would probably have to be early or late for expansive views and nice detail in the lake beds. I have only driven through this area, from Idaho to the Klamath Falls area. I know I-5 as well. The north end of the Wallow Mountains are very scenic (Enterprise-Joseph, Oregon area). I spent a lot of time in the Wallowas mostly in winter, about 40 years ago, and again about 12 years ago. Route 12 through Idaho is gorgeous, but is twisty and slow on the eastern half of it.