I have been using a Jobo CPE2 for around 20 years now. I have a fairly good system in place and plenty of records to give me processing times.
However, last week I was presented with a film and developer combination I had never used. Tri-X 400 and Ilford Ilfotec LC29. They were not my films or developer, but one of my students work.
As she is at a stage where decisions need to be made by her, she decided to go with the times published on the Harmon site.
No Pre-wet, dilution at 1+19 and processing at 21ºC. The films were very printable with most of them being printed at grades 3 to 3¼.
The next lot of films were processed with a ¼ of a stop more processing time, they printed at grades 2¾ to 3. She will be sticking with the this later, time, temperature and developer combination outcome for future use, it works well for her.
You can do a pre-wet or none, whatever you find works well, keep on doing it. I would suggest that the manufacturers published developing times with their films and developers are quite close for starting points. That is the experience of myself, and the students I have taught.
Mick.