I have been using the a Jobo CPE2 with lift, (original model) for around 30 years. I have been doing 4x5" film, C41, E6 and B&W over the decades in the Jobo with the 2509 reels and loader, brilliant.
I was one of the recipients of the kickstarter SP-445 program and received my tank a couple of years ago. The intention was to use it on long trips (think months) and develop 4x5" film as I travelled, so part time use. Well, the SP-445 turned out to be so nice and easy to use that after around 6 months, I stopped using the CPE2 for 4x5" developing and just used the SP-445.
This turned out to be a good thing as my Jobo died recently, after literally, thousands of film processes. I do not at this stage, think I'll actively seek out a replacement for the Jobo, as 4x5" film is pretty much all I do these days and the SP-445 is so easy to use and gives remarkably good negatives every time.
Mick.