I have no experience of forced ventilation but I would reason that if you adopt negative pressure, you expel air of your darkroom and all the bad smells of chemicals, and you have air from the rest of your house leaking in, which may have dust, but does not smell.
If you adopt a positive pressure situation, you get fresh air from outside, and you can filter it from dust, but you will push smell of chemistry in the rest of your house. So if you have other rooms in your basement, that you use for your everyday life, I would think twice before adopting positive pressure.
The best solution is probably as it is done in offices, forced ventilation in, forced ventilation out, you can choose between slight positive pressure and slight negative pressure, but the double fan solution should be superior in any case. You could install a duct that brings air deep inside your room, and a vent to expel it from a peripheral wall.
Fabrizio