Damn, Bill beat me to it, but still I'll say no, as long as:
- you've got enough developer per roll (check datasheets)
- you've got enough liquid covering the film
- your reels don't move upwards (some people advocate putting empties on top to fill the tank).
Actually, I've heard people actually advocating this, ie to always use a half-full tank. Something about making it always re-mix the chems properly (which I can understand, in a full tank with 0% air, the liquid won't be as mobile and mix each inversion).
Also watch out, if you've always 'stirred', you'll get different contrast and maybe different developing times when inverting (if you've calibrated enough to notice).