If you search on Imagon here and at the LF Forum you will find lots of info. Rather than repeating all the details here are a few simple guidelines:
1) The 250 is specifically designed fo use with 4x5.
2) Hard light works best (as noted above).
3) You need to focus the lens at the taking aperture. A simple trick to do this is to have your subject hold a small led point source light at the pointyou want in sharp focus. When you have a clear, sharp star pattern of that light you have the focus right (thanks to Bob Salomon of HP MarketingCorp for this).