I am using FP4+ 4x5 and using a Jobo for processing, I also use D76 1+1, which is a developer I have been using for years.
I think you shouldn't have too many problems getting a reasonably fine grained picture at that enlargement. I only enlarge to 12 x 16" paper but sometimes I crop from what would be a 20 x 24" enlargement or bigger. At that enlargement, grain is evident, but you really are looking, don't forget that grain is a fact of life with film.
Different lenses have different contrast and sometimes I find that I can shoot with my Fujinon W 210 f5.6 which is something like 20 years old without a filter, when I switch to the Schneider Angulon 90 f6.8, I really find an orange filter brings the contrast in line with the Fujinon, then both negs from each lens, enlarge almost identically, with near identical characteristics.
As for grain, well you may find a slight performance between different developers, but by and large it has been my experience over the years that a film has a certain grain size and different developers with different dilutions can and do make a difference, but it usually isn't that great.
I use D76 1+1 and have found that the film is more than usable with great possibilities between 80 - 100 ASA in normal daylight. You really will have to suck it and see, with some personal testing. Under Tungsten light, I find that 64 ASA and developing for a higher contrast, works well for me.
Rotary developing should give you consistency, sheet after sheet. I use old reels that I bought new for my 2800 drums about 19 years ago. The reels hold six sheets, but I have tested with six sheets and found there were quality control problems and apart from a test run with six sheets, I have only ever developed four sheets to a reel with near perfect developing results, this includes E6, C41 and B&W.
Mick.