Large format negatives are an absolute joy to print in terms of tonality and detail, and an absolute horror to spot, especially if any lack of scrupulous cleanliness lead to dust on the film, which causes a white spot on the negative that prints black. You can try scratching the surface of the print lightly, which never works, or bleaching it back, which leaves an area the size of Texas with a ring around it you can't blend in or, most satisfactorily though that isn't saying much, spot the negative, leaving a white spot on the print that, if you are very careful, will only be the size of Montana, not Texas, and can be dealt with using the usual methods. Even if you are careful and lucky enough (and there is an element of luck no matter HOW careful you are, short of absolute clean room conditions most of us can't create) to have no spots on the negative that print white, you have so much more negative real estate to keep clean in printing, though this is somewhat offset by the smaller enlargement factor meaning you just won't see the smallest spots where you might from a smaller negative at higher enlargement.
In comparison, going to medium format from 35mm gives you about 75% of the increased printing ease and quality relative to the 35mm-4x5 jump with virtually none of the increased dust hassles, not to mention the loading-holders-in-general hassle.
I enjoy working with a view camera, movements are occasionally useful, and when everything is right and the stars align those big negatives are wondrous, but I really see medium format as the sweet spot for quality versus hassle.