What is your application?
Indeed hypering fell out of favour some time ago for various reasons. You can still do it of course, but what most astro types do now is stack images. There is excellent software for that. You could also stack negs by hand in order to achieve more or less the same effect, but registry will be a challenge and the exposures will get quite long if you have a lot of negs! The most I have done was two and that was for a 5x7 contact print. If you do it electronically then it is easy.
So for example you can shoot at whatever ISO you need, even if it is quite high, and reduce the noise/grain by stacking the images. The film grain is random so it will average out to smoother tones, whereas the real information is not random and will emerge more clearly. With this technique it should be possible to, e.g., shoot the moon at ISO 3200, stack ten frames or so, and get excellent tonal detail with almost no grain at all. Of course, the big fly in the ointment is subject motion, but if you simply align the subject from frame to frame...