I've spent many, many years working with B&W chemicals, and no health problems. I do wear a resperator when mixing the dry chems, as they have a tendancy to "fluff up" a bit in the air. I think the damp air in my basement dark room may be more of a health hazard than the fumes from my tray of Dektol. I would be more concerned with the color chems. They have alot of pretty toxic stuff in them. Again I have spent many years around E-4, E-6, C-41, and RA4 stuff, and I still feel pretty good at 58. I could tell you horror stories about a commercial lab I worked at for almost 10 years.