An excerpt from the Vuescan manual:
"The basic idea is scanning each pixel more than once and averaging the pixels. Each doubling of the number of pixels increases the effective number of useful bits of data by one. For instance, if you have a 10-bit scanner like the Nikon LS-30 and you read the CCD 4 times at each pixel position, you get effectively 12 bits of useful image data.
There are several ways of achieving multiple image samples. The first is single-pass multi-scanning. Some scanners are capable of reading each pixel position multiple times before advancing the scan head to a new position. The second technique is multi-pass multi-scanning, which most scanners are capable of (however, some can't accurately reposition each scan pass, so this may not always work well)."
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Maximizing Image Quality