IMO it depends on what you plan to put on top of the tripod and how you plan to use it. To minimize vibration, ideally one would eschew use of the center post, but many of the new center posts have features that make them desirable, such as hooks to add weight for stability or special adjustments that make awkward positions possible.
For instance, current Manfrotto 3021 has a center post that can be extracted and repositioned in the top of the tripod to run perpendicular to its normal orientation. I am quite fond of using that feature with my Pentax 67 for images straight below the tripod. I'm not as confident that it would work as easily with the 4x5 due to the weight, but I'm sure it could be done.
And since the 3021 doesn't quite make it to eye level with its legs fully extended, on occasion, I find it handy to goose it up a bit now and then with my 4x5, and even more on with the 67.
That same tripod has a feature that looks to be a PITA that permits one to have the tripod legs splayed flat, with the head only inches above the ground. But, it involves actually unscrewing the tripod head from the center column and reattaching it to this little triangular piece. I find it much easier to just invert the center column and work between the legs, or use that perpendicular feature I mentioned earlier.
Since I am carrying multiple formats in my bag anyway, I find I prefer the flexibility that having a center post provides, but just use it with an eye on minimizing any of the issues it might introduce.