I'm not sure what you mean by large tank? Do you mean a 2xxx series tank? I also have several Jobo 2509N 4x5 sheet film reels that go into the 2xxx series tanks. If you're referring to these then the main difference is the agitation that the film gets. If you're picky about even development, the 2509N real does a good job but may show uneven development around the perimeter of the film, and the development for sheets on the outer ring of the reel is not the same as that for sheets closer to the inside or middle of the reel. The 3010 does an amazing job at even development over the entire film surface.