Did you update your computer since your last scanning session? If so, make sure your scanning software is up to date, and see if Epson's own scanning software works.
And are you certain that you were using the exact same USB cable as previously? Because it's super-common for cables bundled with a device to have only a subset of the pins connected, often just the bare minimum for that specific device. That's why I have set aside a specific cable for use with my scanner, because I know that all of the pins are properly wired.