I use Epson scan software at 48 bit 2400dpi. Save as TIFF. No ICE, won't work anyway with BW. Clone out the dust spots in the film from the scan right away. No sharpening in the scan; Normally, no other scanning adjustments. I do all in Lightroom; sometimes with Elements. Sometimes I set the color to auto during the scan. Sometimes that works. Sometimes it clips the highlights. So I adjust the Levels. The most important adjustment for me is Levels. Moving the black and white sliders will restore the colors and lighting about 90%. Tweak other sliders for the last 10%. Sharpen a lot at the end. I don't have Vuescan.
Try scanning the same shot different ways and compare. In the end you have to develop your own workflow. Good luck.