I'm not sure about the V550, but on the V700 I have found that scanning in positive mode can increase the scanner's dynamic range. It does of course mean that you have to manually invert the scan and do some work to get good tonality and colour (if it's a colour neg). You also should use 16 bit TIFF mode. Dense areas are captured with better tone and less noise.
On the V700, equivalent scans take much longer when in positive mode rather than negative mode, which would mean that exposure is longer for each sample, meaning more light is gathered. This would make sense, given that the maximum density of positive film frames is generally much higher than that of negative film frames. If the V550 takes longer to make equivalent scans in positive mode, then I'd say you're likely to get a benefit.
I would recommend manually altering the black/white points in the colour histograms to ensure you capture the full dynamic range.