+1 on what Ian said.
Refrema's can be hungry beasties, requiring large(r) amounts of film to be run vs a Jobo-style setup. My E-6 lab(
www.data-chrome.com , totally awesome lab btw, they also take mail-order) uses a Refrema, and the lab owner/operator Rochelle told me the other day it takes 101L of chemistry for EACH of the 1st Dev, Color Dev, Pre-Bleach, Bleach, and Fix tanks. The wash tanks are smaller, about 50L or so. But she doesn't have the smaller machine, since she's running film for multiple photo stores, and Samy's processing from the Santa Ana store, along with other customer's/students/pro photographers film that comes in. LOTS of chemistry
A good "pro" lab will run test strips and actually measure them for density and color balance. They can adjust the replenishment levels on the machine to coordinate things into the guidelines mandated by Kodak or Fuji.
Datachrome uses ONLY Kodak E-6 chemistry, fyi
-Dan