I use Acufine and replenisher as my regular tank developer and TF-4 in the fixer tank, but I'll also mix up batches of other developers like ABC or RAF-pyro for one session. I've got 5-quart and 4-quart 5x7" tanks.
With 5x7" tanks, there's more volume of developer per area of film than in trays and less surface area, so I seem to be able to get three batches of film through a tank of ABC or RAF without a problem, though in trays it's generally recommended not to do more than two batches.
Dave Wooten and I saw the big Refrema dip-and-dunk system (strictly speaking, this is what "dip-and-dunk" refers to) at the Sixty-Eight Degrees lab in New York, and they use Xtol. Those tanks are big enough for 20x24" sheets or 36-exposure rolls of 35mm hanging straight up and down.