I'm not too familiar with PDN, but you might have some difficulty doing it from within LR.
You have to figure out if LR can do 2 things:
1) Output a negative image
2) Accurately colorize the negative
Keep in mind that you may need to figure out your best PDN color, and then figure out the opposite of that color, so you can colorize your positive and output the proper negative.
The R2400 is supported in QTR (QuadTone RIP), so you may want to download that and check it out, too.
Piezography inks, if you get the right set that work well on OHP film, may be an option, especially if you think you will make prints with them as well. But due to the way the curves are created, they are not amenable to a lot of manipulation at the moment. (Another forum user is working on a tool to do that, but it's not released at the moment.)
See here:
http://www.hybridphoto.com/forums/showthread.php?t=2099
Good luck--
Greg