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This is a development artefact cause by insufficient developer volume, or a film reel that was not slid entirely down onto the center column. Essentially, part of the film spent a considerable part of the development time not submerged in the developer.
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This is either a light leak hitting the front of the film, possibly caused while the film was in the camera. Alternatively, it could be a spot of retained silver due to incomplete fixing and/or bleaching, but a light leak seems more likely. You could try running the affected negatives through bleach and fix again and see if that helps. If so, you know where to look.