I have done this with a MacBeth Color Checker using Picture Window Pro. PWP has a utility that allows you to fit a box to the Color Checker in the image, then it adjusts all of the color patches and gray scale to fit an RGB profile of the Color Checker. As long as it's the same film, processed the same, and shot under the same light, and scanned the same, you can use a saved version of the profile created by this tool to color correct subsequent negative scans. Yeah, that's a lot of qualifiers. If the color is critical, you'd do best to shoot a Color Checker frame to match the shot you want.
In practice, I find that it's best if I "homogenize" the Color Checker patches first with a little blurring.
Lee