This shouldn't be happening but it sounds like the mirror is just touching the back of the lens when in the up position. If the lens is focused at infinity, this is the worst case. If you focus the lens at the closest focusing distance does the mirror still stick in the up position? I have a Pentax spottie that will hold the mirror up when focused at infinity.
The fact that loosening the breech lock allows the mirror to return tells me there is an interference problem.