When nikon's software nolonger worked on my mac, it was painful at first to switch to vuescan, but i eventually found it far superior to nikon's software. I don't do post processing in vuescan, nikon, or silverfast, nor have I used scanner film profiles or scanner post processing on imacon's or creo's -- I've tried, but they are never as good as what i have been able to do in software built for image processing (image processing meaning color, density and contrast adjustments). I do create, when available, scanner profiles, but that is not available for the nikon in vuescan that I have been able to find. In vuescan I use 14/16bit color depth, multi exposure, multi sample, fine mode and medium ir cleaning. A 35mm neg tends to be the same pixel size as yours but the file size is in excess of 110mb. Vuescan on the 8000ed requires a a good deal of effort with regard to medium format (6x4.5, 6x6, 6x7, 6x8 and 6,9), but I suspect you won't have that issue.