I've used Direct Positive Paper in a Graflex 4x5 with decent results (was still learning the camera). I also shot some paper negatives using enlarging paper, that I then scanned and reversed to get a positive image. It all worked, the effective ISOs were so low, it was challenging to shoot at times.
I suspect someone experienced and comfortable with LF could get great results, but I was biting off too much at once time (large format, old press camera, paper negatives, etc).
Chris