Over- resp. underdevelopment strongly influence grain appearance (and thereby acutance) in my experience. Pulling C41 film (overexposing and under-developing) results in somewhat 'mushy' and soft images if you look closely. On the other hand, overdeveloping results in somewhat more 'crisp' images. It's a bit of a subtle difference and the terminology is debatable.
Skipping bleaching (or underbleaching, but I wouldn't recommend that, given the risk of unevenness) will also emphasize grain, and reduce saturation at the same time, due to retained silver.
Other variables won't make much of a difference for the most part, except fogging including using (very) expired film, as it scavenged images from fogged C41 film tend to come out somewhat grainy especially if scanned and then contrast-boosted in digital post.
Water quality I wouldn't worry about too much as it's mostly insignificant unless you use some kind of industrial waste water or something. Any reasonable clean tap, bottled or even demineralized water will be fine to mix up commercial developers, bleaches and fixers. Drying/water spots/marks of course are associated with calcium content in wash water, but that's another matter altogether and addressed in many threads on the forum.
To give some context to further discussion: are asking because of troubleshooting an issue, exploration of avenues for creative expression or out of general curiosity?