S lenses don't have clicks at the half stops, but you can still use intermediate stops.
The S 50/3.5 has a 67mm thread like the 80/2.8 and 150/3.5 have, but the PS 50/3.5 has a 77mm thread. This probably lets you do more filter stacking, at the expense of needing another size of filter.
The coatings are better in the PS lenses than in the S lenses, but this doesn't always matter.
I've never used the 50 S, but my 80 and 150 S lenses are very good and I don't feel a need to spend more for more modern lenses. Prime lenses tend not to be as affected by coatings as zooms are anyway.