I've been using COT160 since it was first imported into Australia by Ellie Young at Gold Street. It has very good wet strength and it dries flat. It has handled salt, VDB, Mike Ware's New Cyanotype and Ziatypes well. I have found it easier to use, after years of Arches Platine and COT 320. It is perhaps a personal perception, but COT 160 doesn't "seem" to be as "grainy" as the 320 paper - heavier texture maybe?.
I haven't noticed any differences between in-camera and digital negatives other than, for me, a lack of tonal depth/range in the digital negative prints. I do use both, but usually prefer in-camera negs.
Peter.