I used to have a B-22, and my guess is that there is some buckle, or "pop" occurring, as David suggests, meaning that the center of the neg is raised up from the heat, which it can be with a B-22. Stopping the lens down to a smaller aperature can help with this. If it works, but is too small (times too long) at least you know what the problem is. Also, it's best not to use an f/stop more than 2-3 down from the largest.
My B22 had corner set screws on the negative stage I could use to level it. A simple method, which I used in college, was to take a piece of film the size you are using, make it black (expose to light and develop) - if 35mm, a leader works. Then scratch a big X corner to corner, then adjust the corner set screws till all corners are sharp. If the center isn't sharp, then you have buckling.
For a better lens, like an El Nikkor, you can get another lens board cut for that size, which, I believe is 39mm, called "Leica" thread. There is a well known web site for vintage Omega enlarger parts, I forget the name, maybe someone can help with that.