Phil,
If I remember right from your other scanning posts, you have a Nikon scanner. That scanner has built-in "Infrared Cleaning." Nikon calls it Digital ICE. Both Nikon Scan and Vuescan support it, but I don't think that Silverfast does. If you use it, you'll find there are different settings for it. You can turn it off, or on at different levels. If I remember right, Nikon scan has a fine and a heavy setting for Digital ICE. Vuescan has a Light, Medium, and Heavy setting. Which setting to use?
Infrared cleaning does not work for traditional black and white films, it produces strange very high contrast tonality. It does work for C-41 process BW films, like Ilford XP2 and Kodak T400CN. It also works for C-41 and E-6 color films. It isn't supposed towork for Kodachrome but some people report getting good results with it.
My experience is that the Light setting does not reduce image sharpness. If my film is relatively clean and is free of scratches, I use this all the time for films it is compatible with. For scratched or very dirty films that cannot be cleaned (dust embedded in the film), the medium and heavy settings work but will cause some loss of fine detail. Try the Medium setting first, and only use Heavy if the film is really bad.